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Observe Carefully (1)phenobarbital will minimize the level or result of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to the reduce in fentanyl plasma concentrations, not enough efficacy or, possibly, advancement of a withd